Background: Migraine is a highly prevalent, debilitating chronic neurological disorder characterized by recurrent, unilateral, throbbing headaches. In Ayurveda, it closely correlates with Ardhavabhedaka, a disease primarily driven by the vitiation of Vata and Pitta doshas. Conventional pharmacological management often yields incomplete relief and carries the risk of medication-overuse headaches and adverse side effects. Case Presentation: A 34-year-old female patient presented with a 5-year history of severe, unilateral, pulsating headaches, accompanied by photophobia, phonophobia, and nausea. Conventional analgesics and triptans provided only temporary relief. Her condition was diagnosed as Ardhavabhedaka based on Ayurvedic diagnostic principles. Intervention: The patient was managed using a comprehensive Ayurvedic protocol with a primary focus on Pratimarsha Nasya (nasal drug administration) using Brahmi Ghrita, preceded by Snehana (oleation) and Swedana (sudation). This was supported by Shamana (pacifying) oral medications, including Pathyadi Kwatha and Godanti Bhasma. Outcomes: Treatment efficacy was measured using the Visual Analog Scale (VAS) for pain intensity and the Migraine Disability Assessment Scale (MIDAS). Over a 30-day treatment period and a subsequent 60-day follow-up, the patient's VAS score dropped from 8 to 1, and the MIDAS score reduced from 22 (Severe Disability) to 4 (Little or No Disability) .Conclusion: Ghrita Nasya, combined with supportive oral Ayurvedic formulations, demonstrates profound efficacy in managing Ardhavabhedaka (migraine). The lipid-soluble nature of Ghrita facilitates efficient drug delivery to the central nervous system, effectively pacifying Vata and Pitta and providing long-term relief without adverse effects.