Background: Chronic kidney disease (CKD) is a progressive clinical condition characterized by persistent structural or functional abnormalities of the kidneys lasting for more than three months. Progressive deterioration of renal function may lead to fluid retention, electrolyte imbalance, anemia, cardiovascular complications, and end-stage kidney disease. In Ayurveda, the clinical manifestations of CKD may be understood through the concepts of Mutravaha Srotodushti, Mutraghata, Agnimandya, Srotorodha, and progressive Dhatu Kshaya. Case Presentation: A 55-year-old male patient presented with bilateral pedal edema, generalized weakness, fatigue, reduced appetite, decreased urine output, and exertional dyspnea for six months. The patient had a history of hypertension for eight years. Laboratory investigations revealed elevated serum creatinine of 4.2 mg/dL, blood urea of 85 mg/dL, estimated glomerular filtration rate (eGFR) of 15 mL/min/1.73 m², and urine albumin of.Based on the clinical findings and laboratory investigations, the patient was diagnosed with Stage 4 chronic kidney disease. Intervention: The patient was treated with an individualized Ayurvedic protocol consisting of Punarnavadi Kashaya, Gokshuradi Guggulu, Chandraprabha Vati, and Punarnava Mandura. Matra Basti with Bala Taila was administered for eight days. Dietary modifications, salt restriction, controlled fluid intake, and lifestyle advice were provided according to the clinical condition. Outcomes: After three months of treatment, improvement was observed in pedal edema, appetite, fatigue, urine output, and general well-being. Serum creatinine decreased from 4.2 mg/dL to 2.8 mg/dL, blood urea decreased from 85 mg/dL to 56 mg/dL, and eGFR increased from 15 to 24 mL/min/1.73 m². The findings of this case indicate that an individualized Ayurvedic treatment protocol, along with appropriate dietary and lifestyle modifications, may have a supportive role in improving clinical symptoms and renal function parameters in patients with CKD.