Background: Amavata is a chronic inflammatory disorder characterized by joint pain, swelling, stiffness, and restricted movements. Based on similarities in clinical manifestations, it may be clinically correlated with rheumatoid arthritis (RA). Impairment of Agni leads to the formation of Ama, which, in association with aggravated Vata Dosha, becomes localized in the joints. Case Presentation: A 42-year-old female presented with symmetrical pain and swelling involving multiple joints, morning stiffness lasting 90 minutes, fatigue, reduced appetite, and restricted joint movements. Laboratory investigations revealed elevated erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor, and positive anti-cyclic citrullinated peptide antibodies. Intervention: The patient was treated with Deepana-Pachana therapy, Valuka Swedana, Vaitarana Basti, Simhanada Guggulu, Amavatari Rasa, Rasnasaptaka Kashaya, and appropriate Pathya-Apathya for three months. Outcome: Improvement was observed in joint pain, swelling, tenderness, morning stiffness, and functional capacity. ESR decreased from 68 to 24 mm/h, CRP from 18.6 to 4.8 mg/L, and DAS28-ESR from 6.2 to 3.1. No adverse effects were reported. Conclusion: The individualized Ayurvedic treatment protocol was associated with improvement in clinical symptoms, inflammatory markers, and disease activity. Further controlled clinical studies are required to validate these findings.